Electrochemical CRISPR Can Be Used for Extremely Quick Blood Test

Electrochemical CRISPR Can Be Used for Extremely Quick Blood Test

We are searching data for your request:

Forums and discussions:
Manuals and reference books:
Data from registers:
Wait the end of the search in all databases.
Upon completion, a link will appear to access the found materials.

Parts of the scientific community hope that the gene-editing tool, also known as CRISPR, will be a scientific miracle that will eradicate diseases and fight cancers.

Others aren't so quick to sing its praises, saying it will be used to create designer babies and further widen the inequality gap.

Researchers at Case Western Reserve University have been working on a different use altogether for CRISPR: a new "universal bio-sensing" point-of-care medical device that can rapidly and efficiently detect viruses.


An extremely fast device

In order to develop their "universal biosensing" device, the researchers converted the CRISPR "recognition induced enzymatic signal" to an electrical signal. This allowed them to use it to detect the biomarkers for viruses such as human papillomavirus (HPV) or parvovirus (parvo).

"This could someday become a simple, accurate and cost-effective point-of-care device for identifying different nucleic acid viruses, such as HPV or parvo from a single droplet of a blood sample," Yifan Dai, a Ph.D. candidate in the chemistry department and lead author of the paper, explained in a press release.

"And it would also be extremely fast."

As Dai explains, existing tests for those viruses currently take up to five days for an accurate result, and they can be costly. The bio-sensor envisioned by Case Western Reserve researchers, meanwhile, would allow for accurate results in less than an hour.

It would be particularly useful in the case of viruses like Parvovirus B19, or parvo, where two out of 10 people infected have no symptoms, and HPV, a common virus that can lead to six types of cancers later in life.


While CRISPR has been tested mainly for cutting and editing DNA, 'E-CRISPR' is the name Dai and co-authors have given for their bio-sensing device application of the technology.

The device is what they call an "electrochemical platform," which relies on the precision of the CRISPR technique to identify viruses in a person's bloodstream with incredible efficiency.

"The CRISPR technique works so that it cuts all of the nonspecified single-strand DNA around it once the target is recognized, so we program to electrochemically probe this activity," he said.

"No virus — no cutting, it's that simple. And the opposite is true: If CRISPR starts to cut, we know the virus is present."

Watch the video: CRISPR Cas9: How CRISPR can be performed in the lab? (July 2022).


  1. Caladh

    Matchless topic, it is pleasant to me))))

  2. Gukazahn

    Make mistakes. I am able to prove it. Write to me in PM.

  3. Rigel

    It here if I am not mistaken.

  4. Devereaux

    the Competent answer

  5. Zarek

    No, on the contrary.

  6. Colin

    People in ancient times did not like to talk a lot. They considered it a shame for themselves not to keep up with their own words ...

  7. Moki

    I mean, you allow the mistake. I can defend my position.

  8. Muraco

    I have repeatedly read similar posts on English-language blogs, but it does not come out that I did not like your post

  9. Weallere

    I am sorry, that has interfered... This situation is familiar To me. It is possible to discuss. Write here or in PM.

Write a message